high purity 99% lactoferrin Lactoferrin Powder   
Product Description 
Lactoferrin is one of the components of the immune system of the body; it has antimicrobial activity (bacteriocide, fungicide) and is part of the innate defense, mainly at mucoses. In particular, lactoferrin provides antibacterial activity to human infants. Lactoferrin interacts with DNA and RNA, polysaccharides and heparin, and shows some of its biological functions in complexes with these ligands.
Sample Display  
Physical and chemical properties
The affinity between lactoferrin and iron ion is very high, which is 250 to 300 times that of transferrin. According to the difference of lactoferrin binding iron ions, it can be divided into three types: iron deficiency type, iron semi-satiation type and iron saturated type. Different types of lactoferrin have different ability to resist pasteurization thermal denaturation, among which iron-saturated type has the strongest resistance and iron-deficient type has the weakest resistance. Lactoferrin can not only bind Fe3+ and Fe2+, but also bind Cu2+, Mn2+ and Zn2+ [3].
Regarding the thermal stability of lactoferrin, it was found that heat treatment at 72ºC for 20s or 135ºC for 8s had little effect on the iron-binding capacity of lactoferrin, but if the treatment time was prolonged at both temperatures, the iron-binding capacity would be reduced. The heat treatment intensity of 85ºC for 10min did not affect the antibacterial activity of lactoferrin. In addition, studies have shown that lactoferrin degrades after treatment at 120ºC for 5min at pH2.0 or pH3.0, but the antibacterial activity of the degradation products is higher than that before treatment. This result led to the discovery of lactoferrin active polypeptides. Lactoferrin has inhibitory effect on both gram-positive and Gram-negative bacteria, but it has stronger effect on Gram-negative bacteria. The iron saturation of lactoferrin was negatively correlated with bacteriostasis. The change of environmental pH value affected the inhibitory effect of lactoferrin on gram-positive bacteria, but had little effect on Gram-negative bacteria. When pH is 7.5-8.0, the bacteriostatic effect is the best. After pasteurization below 70ºC, lactoferrin has no effect on antibacterial activity. The increase of HCO3- concentration is conducive to enhancing its antibacterial activity .
Product Function  
1. Antibacterial activity
The first biological function of lactoferrin to be discovered and studied extensively is its bacteriostatic ability. Lactoferrin has a broad spectrum of anti-gram-positive bacteria, gram-negative bacteria and fungi, can effectively inhibit the growth of Escherichia coli, Salmonella typhi, streptococcus, Legionella pneumophila, Staphylococcus aureus.
2. Antiviral activity
Lactoferrin helps protect the body against a variety of viruses. Intestinal infections caused by rotaviruses, enteroviruses, and adenoviruses can all be treated with lactoferrin, which inhibits adenovirus replication in the early stages of infection and prevents the virus from attaching to target cells to prevent infection. In the study of norovirus causing infectious diarrhea, it was found that lactoferrin can reduce the damage of cytotoxin, reduce the number of viral cells, prevent the adhesion of virus to cells, inhibit the replication of the virus and increase the expression of antiviral cytokines, thus killing norovirus.
3. Antifungal activity
Both human and bovine lactoferrin and lactoferrin-derived peptides have in vitro activity against human pathogenic fungi, especially Candida albicans and several other candida species. Lactoferrin acts as an anti-bacterial agent, killing Candida albicans and Clostridium cruze by changing the permeability of the cell surface. Lactoferrin can change the permeability of cytoplasm and mitochondrial membrane of Cryptococcus neoformans and Candida albicans. The antifungal mechanism of lactoferrin is achieved through interaction with the cell surface rather than iron deprivation
Step 4 Fight cancer
In recent years, the anticancer effect of lactoferrin has been widely reported. Oral administration of bovine lactoferrin to rodents inhibited chemically induced tumor formation.
5. Immunoregulatory and anti-inflammatory activities
Because lactoferrin is widely distributed in the exocrine fluid of the body, it can participate in immune regulation as the first natural immune barrier of the body. Lactoferrin is one of the important inflammatory response regulators and an important component involved in the regulation of the immune system, which can protect the body against microbial infection, reduce the incidence of Escherichia coli and infectious diarrhea, and improve the growth of newly weaned piglets.
5. Enzyme activity
Lactoferrin can function as an enzyme in some catalytic reactions.
Product Application 
The extensive biological functions of lactoferrin determine its application in cosmetics, food, animal production, medical treatment and other fields, and can be used as antioxidants, immune promoters, iron supplements, drug carriers, etc. 
1. Cosmetics
Lactoferrin is a kind of natural substance in human body, which has a wide range of antibacterial, anti-inflammatory, inhibiting melanin and promoting collagen formation, so it can be used as an effective ingredient in the development and utilization of cosmetic preparations. In the development of whitening cosmetics, the raw material has a certain stability in the processing process, and lactoferrin has a high stability, which can be used as a raw material for processing into whitening agents. Studies have shown that lactoferrin can reduce the formation of melanin, and the ability to inhibit melanin is directly proportional to the content of lactoferrin, which indicates that lactoferrin can be absorbed by the skin, thus playing a role in whitening. Lactoferrin can promote collagen synthesis of osteoblasts in human body, make up for the loss of collagen caused by age factors and environmental factors, and play a whitening effect on human skin.
2. Food industry
As of 2023, there is a wide variety of products containing lactoferrin on the market, including yogurt, buttermilk, health foods and fermented dairy products. In the late 20th century, Japanese dairy companies began to produce and sell infant formula containing lactoferrin. Lactoferrin has many benefits when added to infant milk powder, including promoting iron absorption and improving intestinal flora. The health benefits of these products containing lactoferrin have been demonstrated in clinical and animal studies. Japan, South Korea and other countries and regions are popular in fermented dairy products, infant food, soy protein products, meat products to add lactoferrin, supplement lactoferrin, enhance the body's immunity, prevent the body from virulent cold, intestinal infection and other diseases
3. Animal production
When lactoferrin is added to the sow's feed, the sow can obtain a large amount of endogenous lactoferrin, which can reduce the probability of iron deficiency anemia in piglets, improve the immunity of piglets, and promote the growth of piglets. Adding lactoferrin to piglets' diet can improve intestinal microflora, prevent intestinal diarrhea and enhance the absorption of nutrients in piglets' intestines. The feed with lactoferrin can prevent the feed from being decomposed by oxidation and enhance the nutrient content of the feed at the same time. Lactoferrin also has a better role in maintaining its physiological function during the high temperature processing of feed, so it can be used as a green feed additive for animal feeding
4. Illness
Lactoferrin not only regulates the body's iron metabolism, but also plays an important role in the body's anti-inflammatory and antioxidant. Lactoferrin receptors exist on the surface of cell membranes and have a molecular weight of about 105 kDa. Common target cells include mucosal epithelial cells, hepatocytes, monocytes, macrophages, lymphocytes, and bacteria such as Staphylococcus aureus and pseudomonas. Lactoferrin binds to bacterial cell surface receptors and can activate intracellular signaling pathways or enter the nucleus through endocytosis to participate in immune and bacteriostatic functions. Studies have confirmed that lactoferrin receptor is highly expressed in neurons and capillary endothelial cells of the brain of patients with Parkinson's disease, and lactoferrin binds to it to inhibit the transmission of prion protein. This role of lactoferrin suggests its potential application in the prevention and treatment of neurodegenerative diseases.

Our Company 
Baoji Runyu Bio-Technology Co., Ltd. is a high-tech enterprise specializing in the development, extraction, 
processing of active ingredients from natural plant extracts and herbal extracts, as well as the production of 
pharmaceutical intermediate, monomer and health care products.
Baoji Runyu Bio-Technology Co., Ltd. has a high-quality production, R&D, and management team with professionals
 who are engaged in the plant biotechnology research and development for over 15 years. Our company attaches
 importance to the product development, we not only develop new products by ourselves but also cooperate with
 domestic famous factories, colleges and universities, and laboratories in the industry actively. In addition, our company
 has a series of advanced production equipment such as the preparation, extraction, leaching, chromatography, concentration,
 purification, and vacuum drying equipment of pure water, as well as high performance liquid chromatography (HPLC) and various 
experimental analysis equipment. In order to ensure the quality of our delivery products, strict management procedure for production
 is executed.
Our company's main products cover Huperzia Serrata Extract - Huperzine-A, Horse Chestnut Extract - Aescin, Polygonum Cuspidatum
 Extract/Grape Skin Extract - Resveratrol, Butcher's Broom Extract - Ruscogenin, Phloretin, Okra Extract, Curcumin, Sinomenine Hydrochloride, 
Berbamine Hydrochloride, Ginseng Extract - Ginsenoside, Evodiamine, Dioscorea Nipponia Extract Diosgenin, Celangulin, Tetrahydrocurcumin, 
Xanthin, Zeaxanthin, Ursolic acid, Naringin and Neohesperidin series products, Luteolin, Nattokinase, Piperine, Paeoniflorin, Pjosphatidylserine.
 
Most of our products are sold to inland, Macao and Taiwan, Europe and America, Southeast Asia and other countries and regions, enjoy high
 popularity in these places and become the preferred products of many pharmaceutical, food, health care products and cosmetics production 
enterprises at home and abroad.
Packing and Shipping
Delivery time :Within 3~10 working days after receiving the confirmed payment
MOQ : 1KG
Net Weight : 25kgs/Drum
Gross Weight : 28kgs/Drum
Payment :T/T,paypal or Alibaba Payment,If you need other payment methods, please contact us.
Freight : The freight cost will charge according to the destination detailed quantity.
Storage : Stored in dry and cool place, keep away from strong light and heat.
Shelf Life :Two years when properly stored.
OUR SERVICE
 1. We inspect the manufacture process strictly and the quality can be controlled.
 2. We supply high quality products, reasonable price, prompt delivery.
 3. Our products are natural,pure and no additives. 
 4. Free Sample To Test Quality First is Accepted.
 5. Our products can be OEM,packaging can be done according to the yours requirements.
 6. After SalServices 24*7.
FAQ:
1.What's the min order for the usual?
  15kg. As for the high-value products, min order starts from 1g or 10g.
 
2.What's the sample cost?
  Free samples for normal products. Will charge on high-value products like huperzine-A.
 
3.What's the package and payment terms?
  We pack with 2 layers of food-grade plastic bags inside and aluminum foil bag outside, 10-25kg/drum.And payment terms are normally T/T & Western Union. 
 
4.What's the shipping time?
  May take 3-5 working days to Asia or surrounding countries by EMS etc..
  5~10 working days to European or Americ countries by EMS etc..
 
5.How do we do if the goods doesnt match with the sample?
  Usually we'll confirm the testing method, if it is because of the quality, we''ll recalled the unquality goods and send free the products to you again. Please don't worry, our products were tested before the shipping.