• Gastric inhibitory polypeptide receptor (GIPR) agonist:   As a GIP receptor agonist, retatrutide enhances appetite suppression and prevents fat accumulation, resulting in decreased energy intake and increased energy expenditure.
• Glucagon-like peptide 1 receptor (GLP-1R) agonist:   Retatrutide reduces body weight by improving blood sugar levels via enhanced insuli release from the pancreas and reduced release of glucagon (a hormone that increases blood sugar).
• Glucagon receptor (GR) agonist:   Retatrutide decreases glucagon release to improve blood sugar levels, decrease food intake, and increase energy expenditure which ultimately results in weight loss.

BENEFITS OF GLP-1 AGONISTS

• Helps slow food leaving your stomach
• Helps prevent your liver from making too much sugar
• Helps the pancreas produce more insul when your blood sugar levels are high
• Can help control blood glucose
• Can reduce hyperglycemia, especially after meals
• Can reduce fasting insul and fasting glucose
• Can reduce hemoglobin A1c
• Can decrease appetite and caloric intake, while inhibiting weight gain
• Has been shown to lower triglyceride levels and oxidative stress from high LDL
• Has been shown to help induce weight loss in obese patients with higher dosing
• Helps decrease leptin and increase leptin sensitivity
• Can increase the conversion of white fat to brown fat