Thymopentin is a five amino acid fragment of thymopoietin that exhibits immunostimulatory and anticancer activities.

Thymopentin decreases iNOS activity in the treatment of Sezary Syndrome, a severe form of lymphoma.

In leukemia cells, thymopentin inhibits proliferation and colony formation and induces differentiation.

In macrophages, thymopentin increases pro-inflammatory cytokine secretion, activation of NF-κB, production of

HSP72, and signaling by JNK.

Thymopentin shows clinical benefit when used as an adjuvant, improving the response rate in subjects administered

hepatitis B vaccines.