Lapatinib CAS 231277-92-2 Treatment of Breast Cancer

Model NO.
PY202303211127
Colour
White
Transport Package
1kg/Aluminum Bag or 25kg/Drum
Specification
99% min
Trademark
Puya
Origin
China
Production Capacity
5000kilogram/Month
Reference Price
$ 4.50 - 18.00
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Product Description

Lapatinib CAS 231277-92-2 Treatment Of Breast Cancer
Product Name:    Lapatinib
Synonyms:    lapatinib;n-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]-2-furyl]quinazolin-4-amine;4-Quinazolinamine, N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-;Lapatinib(TINIBS);Lapatinib Base N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-4-Quinazolinamine;GW2016 LAPATINIB;N-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)furan-2-yl)quinazolin-4-amine;N-{3-chloro-4-[(3-fluorobenzyl)oxyl]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)furan-2-yl]quinazolin-4-amine
CAS:    231277-92-2
MF:    C29H26ClFN4O4S
MW:    581.06
EINECS:    1806241-263-5
Product Categories:    Inhibitors;Anti-cancer&immunity;Pharmaceutical intermediate;APIs;API;Lapatinib;Molecular Targeted Antineoplastic;anti-neoplastic;231277-92-2
Mol File:    231277-92-2.mol

Lapatinib is a drug targeting breast cancer developed by British GlaxoSmithKline Co.
Human ErbB receptors belong to the type I tyrosine kinase (TK) receptor family, including ErbB1 (EGFR), ErbB2 (HER2), ErbB3 (HER3), and ErbB4 (HER4). The ErbB-1 (EGFR) and ErbB-2 (HER-2) receptors are often overexpressed or otherwise altered in cancer patients. Human epidermal gro wth fact or receptor 2 (ErbB-2, HER-2) is known to be a human oncogene closely related with breast cancer. Its high expression in breast cancer often predicts lymph node metastasis and poor tumor differentiation, with poor prognosis. HER-2 is one of the target molecules for breast cancer-specific therapy. Lapatinib can act simultaneously on both Her-1 Her-2. The biological effects of this method inhibiting the proliferation and growth of tumor cells are much larger than only acting on one target. The combination of Lapatinib with Capecita bine is used to treat patients with advanced or metastatic breast cancer with overexpression of human epidermal receptor2, already treated with anthracyclines, paclita xel, and trastuzum ab. Clinical trials have shown that Lapatinib also effectively treats HER2-type cancer patients with Herceptin resistance.

Lapatinib CAS 231277-92-2   of Chemical Properties
Melting point     144-146oC
Boiling point     750.7±60.0 °C(Predicted)
density     1.381±0.06 g/cm3(Predicted)
storage temp.     2-8°C(protect from light)
solubility     Soluble in DMSO (up to 200 mg/ml)
pka    6.34±0.19(Predicted)
form     solid
color     Yellow
Stability:    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
CAS DataBase Reference    231277-92-2(CAS DataBase Reference)


Function and Application of Lapatinib CAS 231277-92-2

Lapatinib (CAS 231277-92-2) is a small molecule kinase inhibitor that is used in the treatment of certain types of breast cancer. It works by inhibiting the activity of two proteins that are involved in the growth and spread of cancer cells: epidermal grow th fact or receptor (EGFR) and human epidermal growth fac tor receptor 2 (HER2).

The main function of Lapatinib is to block the tyrosine kinase activity of EGFR and HER2 receptors, which are often overexpressed in breast cancer cells, leading to uncontrolled growth and proliferation of cancer cells. By inhibiting the activity of these receptors, Lapatinib can slow down or stop the growth of cancer cells, thus helping to treat breast cancer.

Lapatinib is usually used in combination with other chemotherapy drugs, such as capecita bine or letrozo le, for the treatment of HER2-positive metastatic breast cancer or advanced breast cancer that has not responded to other treatments. Lapatinib has also been studied in the treatment of other types of cancer, such as lung cancer, but it is not yet approved for these indications.



Packing And Shipping
1.Preferentially DHL, FedEX or TNT for quantity less than 50kg, air shipping for 100kg above, sea shipping for quantity over 500kg.
2.For customers from Russia,Mexico,Turkey,Solvenia,Romania,etc,before placing an order,please kindly confirm if you can make clearance when goods reach your customs.
Shipping Terms
By Express By Air By Sea
Suitable for under 50kg
Fast:3-4 days
High cost
Door to door service
Easy to pick up the goods 		Suitable for more than 50kg
Fast:3-4 days
High cost
Airport to airport
Professional broker needed 		Suitable for more than 500kg
Slow:15-30 days
Low cost
Port to port
Professional broker needed

Lapatinib CAS 231277-92-2 Treatment of Breast Cancer
 

Lapatinib CAS 231277-92-2 Treatment of Breast Cancer
Company Profile
Anhui puya biological technology co.,ltd was established in Hefei. Registered capital is 5 million. It is specialized in manufacture plant extract, API and chemicals raw material powder, food additives and oil. which are applied to skin care, healthcare, weight loss products, sex improvement, and pharmaceuticals. We will uphold honesty and pragmatic, innovative and enterprising service purposes, and provide a variety of quality services to our customers at abroad. It aims at supplying good product and comfort service. The strict quality control is to meet the customer's requirement, to get a highly praised and to be high quality supplier. If you have any question, or need samples, please feel free to contact us.

FAQ
Q1. What's the MOQ?
A: Usually 1 kg.  It is based on the different product. Some are 1g and some are 1 ton. Please be free to consult our salesman.
 
Q2. What's the shipping time?
A: If in stock, we will ship it out immediately.  By FedEx will be 3~5 days to you.
 
Q3. If I need less than the MOQ, is it possible?
A: Yes. Please be free to consult our salesman.
 
Q4. Can you supply the free sample?
A: Usually it is possible. but the shipping cost be paid by customers. It based on the different product. Please be free to consult our salesman.
 
Q5. How to store the product?
A: Store in cool and dry place. It must be in well closed containers. The shelf life will be 2 years.
 
Q6: What's your main payment method?
A: T/T, trade assurance, west union, money gram.
 
Q7: Do you have COA, MSDS, CO, Health certificate, form 9 or other certificate?
A: Yes, we have. pls be free to contact us to get updated one.

 

Organic Intermediate