High Quality Pioglitazone Hydrochoride CAS 112529-15-4 Treatment Of Diabetes 

Product Name:    Pioglitazone hydrochloride
Synonyms:    5-[4-[2-(N-Methyl-N-(2-pyridyl)amino)ethoxy]benzylidine]-2,4-thiazolidinedionehydrochloride;AD-4833;pioglitazone hydrochioride;Pioditazone hydrochloride;PIODLITAZONE HYDROCHLORIC;5-{4-[2-(5-ETHYL-PYRIDIN-2-YL)-ETHOXY]-BENZYL}-THIAZOLIDINE-2,4-DIONE HCL;5-{4-[2-(5-Ethyl-pyridin-2-yl)-ethoxy]-benzyl}-;5-(4-(2-(5-ethylpyridin-2-yl)ethoxy)benzyl)thiazolidine-2,4-dione hydrochloride
CAS:    112529-15-4
MF:    C19H21ClN2O3S
MW:    392.9
EINECS:    629-731-9
Product Categories:    Cardiovascular Series;API;Active Pharmaceutical Ingredients;Antidiabetic;API's;Pioglitazone;Diabetes;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Seleni um Compounds;Inhibitor
Mol File:    112529-15-4.mol


Pioglitazone is a new orally active thiazolidinedione (TZD) launched in the US for the treatment of non-insul in dependent diabetes mellitus (NIDDM). It can be synthesized in 4 steps, the last one transforming an alphabromoester into thiazolidine with thiour ea. As with other representatives in this class, it potently activates the nuclear receptor peroxisome proliferator-activated receptor gamma which is believed to be involved in the regulation of insul in resistance and adipogenesis. In several obese and obese diabetic animal models, treatment with Pioglitazone resulted in reductions in plasma glucose and serum lipids. In clinical studies, Pioglitazone at a once daily oral dose of 15-45 mg, as monotherapy or in combination with non-TZDs or insul in, was shown to significantly improve glycemic control in type-2 diabetes and demonstrated a beneficial effect on insul in resistance and other clinically relevant parameters as plasma levels of triglycerides or HDL-cholesterol. Pioglitazone is reported to be safe and well tolerated and is said to have a lower occurrence of hepatic toxicity as well as a low probability for drug interaction.

Pioglitazone Hydrochoride CAS 112529-15-4  of Chemical Properties
Melting point     193-194°C
RTECS     XJ5813440
storage temp.     2-8°C
solubility     DMSO: ≥10mg/mL
form     powder
color     white to off-white
Water Solubility     Soluble in water (<1 mg/ml at 25°C), DMF, methan ol, ethanol (4 mg/ml at 25°C), and DMSO (79 mg/ml at 25°C).
Merck     14,7452
Stability:    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKey    GHUUBYQTCDQWRA-UHFFFAOYSA-N
CAS DataBase Reference    112529-15-4(CAS DataBase Reference)

Company Profile
Anhui puya biological technology co.,ltd was established in Hefei. Registered capital is 5 million. It is specialized in manufacture plant extract, API and chemicals raw material powder, food additives and oil. which are applied to skin care, healthcare, weight loss products, sex improvement, and pharmaceuticals. We will uphold honesty and pragmatic, innovative and enterprising service purposes, and provide a variety of quality services to our customers at abroad. It aims at supplying good product and comfort service. The strict quality control is to meet the customer's requirement, to get a highly praised and to be high quality supplier. If you have any question, or need samples, please feel free to contact us.

FAQ
Q1. What's the MOQ?
A: Usually 1 kg.  It is based on the different product. Some are 1g and some are 1 ton. Please be free to consult our salesman.
 
Q2. What's the shipping time?
A: If in stock, we will ship it out immediately.  By FedEx will be 3~5 days to you.
 
Q3. If I need less than the MOQ, is it possible?
A: Yes. Please be free to consult our salesman.
 
Q4. Can you supply the free sample?
A: Usually it is possible. but the shipping cost be paid by customers. It based on the different product. Please be free to consult our salesman.
 
Q5. How to store the product?
A: Store in cool and dry place. It must be in well closed containers. The shelf life will be 2 years.
 
Q6: What's your main payment method?
A: T/T, trade assurance, west union, money gram.
 
Q7: Do you have COA, MSDS, CO, Health certificate, form 9 or other certificate?
A: Yes, we have. pls be free to contact us to get updated one.