Puya Supply Top Quality Valrubicin CAS 56124-62-0 Treatment Of  Bladder Cancer

Product Name:    Valrubicin
Synonyms:    ad32;antibioticad32;nsc-246131;n-trifluoroacetyladriamycin-14-valerate;n-trifluoroacetyladriamycin14-valerate;n-trifluoroacetyldoxorubicin14-valerate;trifluoroacetyl-adriamyci14-valerate;trifluoroacetyladriamycin-14-valerate
CAS:    56124-62-0
MF:    C34H36F3NO13
MW:    723.64
EINECS:    680-664-1
Product Categories:    Intermediates & Fine Chemicals;Pharmaceuticals;Antineoplastic;API
Mol File:    56124-62-0.mol

Valrubicin was launched as a new 'chemotherapeutic agent for the treatment of bladder cancer, particularly in patients with BCG-refractory carcinoma in situ (CIS) of the bladder for whom immediate cystectomy is unacceptable. It belongs to the class of anthracyclines, the widest used in human cancers, and is a N-trifluoroacetyl 14-valerate derivative of doxorubicin.Valrubicin can be obtained in 3 steps from daunomycin by N-trifluoroacetylation of the sugar moiety then iodination of the 2-acetyl group and introduction of a valerate residue. A proposed mechanism involved in the cytotoxicity of Valrubicin coud be the blockade of SV40 large T antigen helicase; this cellular enzyme is involved in the formation of a ternary complex with DNA to maintain the topographic structure of DNA during transcription. In patients with CIS of bladder refractory to front line and second line therapies, intravesical instillation of Valrubicin resulted in a complete response with a significant rate and allowed a delay in cystectomy. Systemic absorption was minimal and accordingly produced a lower incidence of cardiotoxicity compared with doxorubicin.


Valrubicin CAS 56124-62-0  of Chemical Properties
Melting point     116-117 °C
Boiling point     135-136 C
density     1.3473 (estimate)
storage temp.     2-8°C
solubility     DMSO (Slightly), Methano l (Slightly)
form     Solid
pka    7.34±0.60(Predicted)
color     Red
Water Solubility     insoluble

Function and Application of  Valrubicin CAS 56124-62-0

Company Profile
Anhui puya biological technology co.,ltd was established in Hefei. Registered capital is 5 million. It is specialized in manufacture plant extract, API and chemicals raw material powder, food additives and oil. which are applied to skin care, healthcare, weight loss products, sex improvement, and pharmaceuticals. We will uphold honesty and pragmatic, innovative and enterprising service purposes, and provide a variety of quality services to our customers at abroad. It aims at supplying good product and comfort service. The strict quality control is to meet the customer's requirement, to get a highly praised and to be high quality supplier. If you have any question, or need samples, please feel free to contact us.

FAQ
Q1. What's the MOQ?
A: Usually 1 kg.  It is based on the different product. Some are 1g and some are 1 ton. Please be free to consult our salesman.
 
Q2. What's the shipping time?
A: If in stock, we will ship it out immediately.  By FedEx will be 3~5 days to you.
 
Q3. If I need less than the MOQ, is it possible?
A: Yes. Please be free to consult our salesman.
 
Q4. Can you supply the free sample?
A: Usually it is possible. but the shipping cost be paid by customers. It based on the different product. Please be free to consult our salesman.
 
Q5. How to store the product?
A: Store in cool and dry place. It must be in well closed containers. The shelf life will be 2 years.
 
Q6: What's your main payment method?
A: T/T, trade assurance, west union, money gram.
 
Q7: Do you have COA, MSDS, CO, Health certificate, form 9 or other certificate?
A: Yes, we have. pls be free to contact us to get updated one.