Free Sample Pmk White Powder Wholesale BMK Pmk CAS 42399-41-7 Diltiazem C22h26n2o4s
Model NO.
42399-41-7
Sample
Avaiable
Transport Package
Various Packaging/According to Your Request
Specification
99%
Trademark
huayiyiyao
Origin
China
Production Capacity
5000kg/Year
Reference Price
$ 36.45 - 40.50
Description
Product Description
| Description | Diltiazem is an orally active L-type Ca2+ channel blocker, with antihypertensive and antiarrhythmic effects. Diltiazem can be used for the research of cardiac arrhythmia, hypertension, and angina pectoris[1][2][3]. |
|---|---|
| Related Catalog |
Signaling Pathways
>>
Membrane Transporter/Ion Channel
>>
Calcium Channel
Research Areas
>>
Cardiovascular Disease
|
| Target |
L-type Ca2+ channel[1] |
| In Vitro | Diltiazem (200 µM) in the superfusate, multichannel currents shows a use-dependent decline in amplitude reflecting reductions in the numbers of superpositions of channel openings in isolated guinea pig ventricular myocytes[1]. Diltiazem reduces Ca2+ influx by accelerating inactivation during action potentials, and that the use-dependent blockade is due to increases in the number of channels in a sustained closed state[1]. |
| In Vivo | Diltiazem (100 mg/kg; p.o.; for 4 weeks) prevents aortic aneurysm formation in a blood pressure-independent manner[3]. Diltiazem limits aortic aneurysm formation in mice by a blood pressure-independent anti-inflammatory effect on monocytic cells[3]. Diltiazem (2 mg/kg; i.v.) has t1/2 of 61.2 min, CLel of 3.2 mL/min[4]. Animal Model: Male ApoE−/− mice, angiotensin II induced aneurysms[3] Dosage: 100 mg/kg Administration: Oral administration, in drinking water, for 4 weeks Result: Srongly reduced the vascular remodeling but also lowered the blood pressure. Animal Model: Rat (200-250 g)[4] Dosage: 2 mg/kg (Pharmacokinetic Analysis) Administration: Intravenous injection Result: T1/2 (61.2 min), CLel (3.2 mL/min) |
| Storage |
Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
| SMILES | CN(C)CCN1C2=CC=CC=C2S[C@@H](C3=CC=C(OC)C=C3)[C@@H](OC(C)=O)C1=O |
| References |
[1]. Yoshinari Niimi, et al. Diltiazem facilitates inactivation of single L-type calcium channels in guinea pig ventricular myocytes. Jpn Heart J. 2003 Nov;44(6):1005-14. [2]. S Lin Tang, et l. Structural Basis for Diltiazem Block of a Voltage-Gated Ca2+ Channel. Mol Pharmacol. 2023 Oct; 96(4): 485-492. [3]. Anja Mieth , et al. L-type calcium channel inhibitor diltiazem prevents aneurysm formation by blood pressure-independent anti-inflammatory effects. Hypertension. 2013 Dec;62(6):1098-104. [4]. S. J. Downing, et al. Diltiazem pharmacokinetics in the rat and relationship between its serum concentration and uterine and cardiovascular effects. Br J Pharmacol. 1987 Aug; 91(4): 735-745. |
Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 594.4±50.0 °C at 760 mmHg |
| Molecular Formula | C 22 H 26 N 2 O 4 S |
| Molecular Weight | 414.518 |
| Flash Point | 313.3±30.1 °C |
| Exact Mass | 414.161316 |
| PSA | 84.38000 |
| LogP | 3.63 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.621 |
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