Application
1. Type 2 diabetes: Semaglutide is primarily used to treat type 2 diabetes, both as a monotherapy and in combination with other diabetes medications.
2. Weight management: Semaglutide has also been approved for use as a weight management medication, specifically for individuals with obesity or who are overweight and have at least one weight-related health condition.
3.
Cardiovascular disease: Semaglutide has been shown to reduce the risk of major adverse cardiovascular events in people with type 2 diabetes and established cardiovascular disease.
4.
Non-alcoholic steatohepatitis (NASH): Semaglutide is being studied for its potential to treat non-alcoholic steatohepatitis, a type of liver disease.
5.
Chronic kidney disease: Semaglutide is being studied for its potential to improve kidney function in people with chronic kidney disease and type 2 diabetes.
6.Alzheimer's disease: Semaglutide is being studied for its potential to improve cognitive function in people with Alzheimer's disease.
Characteristic | Description |
---|---|
Chemical Structure | Synthetic analog of human glucagon-like peptide-1 (GLP-1) |
Mode of Action | GLP-1 receptor agonist that mimics the effects of endogenous GLP-1 |
Half-life | Approximately 7 days, allowing for once-weekly dosing |
Administration | Subcutaneous injection |
Therapeutic Use | Treatment of type 2 diabetes and weight management |
Clinical Efficacy | Has been shown to reduce hemoglobin A1c (HbA1c) levels, promote weight loss, and reduce cardiovascular risk |
Side Effects | Nausea, vomiting, diarrhea, decreased appetite, and injection site reactions |
Contraindications | Hypersensitivity to semaglutide or any of its components |
Interactions | May interact with other medications that affect gastrointestinal motility |
Pregnancy and Lactation | Safety has not been established, and caution is advised for use during pregnancy and lactation |
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