Product introduction
Ibuprofen is often used to relieve pain, reduce fever and reduce inflammation. It is used to treat menstrual cramps, migraines, and rheumatoid arthritis
A common goal in the development of pain and inflammation medicines has been the creation of compounds that have the ability to treat inflammation, fever, and pain without disrupting other physiological functions. General pain relievers, such as aspirin and ibuprofen, inhibit both COX-1 and COX-2. A medication's specificaction toward COX-1 versus COX-2 determines the potential for adverse side effects. Medications with greater specificity toward COX-1 will have greater potential for producing adverse side effects. By deactivating COX-1, nonselective pain relievers increase the chance of undesirable side effects, especially digestive problems such as stomach ulcers and gastrointestinal bleeding. COX-2 inhibitors, such as Vioxx and Celebrex, selectively deactivate COX-2 and do not aff ect COX-1 at prescribed dosages. COX-2 inhibitors are widely prescribed for arthritis and pain relief. In 2004, the Food and Drug Administration (FDA) announced that an increased risk of heart attack and stroke was associated with certain COX-2 inhibitors. This led to warning labels and voluntary removal of products from the market by drug producers; for example, Merck took Vioxx off the market in 2004. Although ibuprofen inhibits both COX-1 and COX-2, it has several times the specificity toward COX-2 compared to aspirin, producing fewer gastrointestinal side effects.
A selective cyclooxygenase inhibitor (IC50=14.9uM). Inhibits PGH synthase-1 and PGH synthase-2 with comparable potency
Cyclo-oxygenase inhibitor; analgesic; anti-inflammatory.
Product Name:
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Ibuprofen
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CAS:
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15687-27-1
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MF:
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C13H18O2
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MW:
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206.28
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EINECS:
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239-784-6
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Melting point
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77-78 °C
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Boiling point
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157 °C (4 mmHg)
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alpha
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[α]D20 -1~+1°(c=1,C2H5OH)
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density
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1.0364 (rough estimate)
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refractive index
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1.5500 (estimate)
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Fp
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9ºC
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storage temp.
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2-8°C
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pka
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pKa 4.45± 0.04(H2O,t = 25±0.5,I=0.15(KCl))(Approximate)
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form
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Crystalline Powder
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color
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white to off-white
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Water Solubility
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insoluble
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Merck
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14,4881
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Company introduction
Wuhan Hansheng New Material Technology Co. Ltd is a professional company which specializeds in manufacturing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents.
We have long term cooperation pharmaceutical raw material production plant and a reagent research and development center, with a rich professional background and strong competitive advantage. We have a professional and experienced team and we promise clients to provide the best quality, price and service. During the business cooperation with clients, we alway adhere principe of Honesty, Trustworthiness and win-win policy. We guarantee 100% qualification of our products pass through the standard of USA, Mexicao, UK, Australia, Canada, Brazil, France, Germany, Spain, Belgium, Sweden, the Netherlands and so on.
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