In our previous study, LZ1 exhibited promising antimicrobial activities against pathogens that are associated with acne vulgaris . Here, we found that LZ1 exerts anti-plasmodial activity. To determine its antimalarial activity, in vitro antimalarial assay against P. falciparum line 3D7 was first evaluated. As illustrated in Figure 1, we examined its activity against the asexual blood stage of P. falciparum parasite. LZ1 showed significant suppression of parasitemia in a dose-dependent manner with a suppression ratio of 98.8% at a concentration of 25 μM. The IC50 value of LZ1 against P. falciparum was 3.045 μM. In addition, LZ1 caused a negligible hemolytic activity to human red blood cells (RBCs) .