PNC-27 is a membrane-active peptide that binds to the HDM-2 protein expressed in the cancer cell membranes of solid tissue tumor cells and induces transmembrane pore formation in cancer, but not in normal cells, resulting in tumor cell necrosis that is independent of p53 activity in these cells. 

PNC-27 is a peptide that contains p53 protein amino acid residues 12-26 of its HDM-2 binding domain attached to a transmembrane-penetrating sequence, also called the membrane residency peptide (MRP). Both PNC-27 and PNC-28 (which has a sequence that is identical to that of PNC-27 but lacks the first six amino acid residues of PNC-27 (i.e., p53 residues 17-26) are lethal to a wide variety of cancer cells with IC50 values ranging from around 75 ug/ml (18.6 uM) to 200 ug/ml (50 uM). On the other hand, neither peptide affects normal or untransformed cells in culture, including human hematopoietic stem cells even at the highest doses (around 500 ug/ml) tested. The latter finding suggests that both peptides would not be toxic to bone marrow function in contrast to the effects of many chemotherapeutic agents.

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Quality:  Purity above 99%, directly produced by the manufacturer, can accept quality testing, and can also customize any content of powder, liquid, oil, etc.

Transport:  We can accept sea freight, air freight, and express delivery, with a guarantee time of 1-2 weeks and a customs clearance rate of over 99%. Even if the goods are detained, you can resend the freight and I will resend the goods.

Service:  We can provide sterile water for you to directly mix and inject freeze-dried powder. In addition to powder, we also have liquids, water-based agents, oils, tablets, and professional customized synthesis routes. We provide you with professional guidance on product use, product synthesis, and product customization.

Price:  We do not engage in price wars. Our first quotation may seem too expensive to you, please don't lose heart. Firstly, our quality can be guaranteed; Secondly, our transportation efficiency and customs clearance rate can be guaranteed; Thirdly, we will provide you with the highest quality service, in any aspect. If you have any questions, I will have the answer.
Company profile
Wuhan EUSANA   Technology Co., Ltd. was established in 2023. Mainly engaged in polypeptide products, synthetic polypeptide amino acids, beauty slimming products, pharmaceutical raw materials and fine chemical products. Has a strong R & D ability, exquisite synthesis technology, advanced quality control means. Effectively promote joint venture cooperation with major enterprises and manufacturers, and serve the society and users with the concept of industrial development. We always adhere to the market demand-oriented, and continue to synthesize new high-tech chemical products and pharmaceutical intermediates, mainly exported to the United States, Europe, South Africa, Nigeria and other countries and regions, there is a great price advantage. We provide samples to test the quality as a trial order, because I have confidence in the quality of our products. Many foreign customers will speak highly of our goods when they receive them. Our products, excellent quality, customs clearance rate 100%, firmly ensure that your goods to your hands door to door.
Our advantage
1. Parcel can be sent out in 24 hours after payment tracking number available.
2. Secure and discreet  shipment verious transportation methods for your choice.
3. Customs pass rate >99%.
4. We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and we have stock in there for transferring.
5.Sample order are welcome.
Our Promise To You:

• Every product we sell is 100 %Authentic & Top Quality.
• Your Satisfaction is 100% Guaranteed or your money back.

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• UK Overnight Delivery.
• Express and Expedite Shipping Available

FAQ
1. How can I get one sample before bulk orders?
Yes. Please leave your sample requirements details by email to Biolink sales team. Technical support anytime after-sales.
2. How does Biolink control the quality of synthetic peptides?
All synthetic peptides are analyzed by HPLC and MS by Biolink QA&QC Team after they approved the quality and leave the factory. We also can supply you with 3rd testing report like Janoshik.
3. How to preserve peptides after receiving them?
Peptides in the form of lyophilized powder can be transported at room temperature by vacuum packaging, while polypeptides in the dissolved state need to be refrigerated at 2°C - 8°C. For long-term storage, peptides should be stored in the form of lyophilized powder store at -20°C or -80°C in a sealed container with desiccant, which can avoid the degradation of peptides to the greatest extent.
4. What is Biolink lead time and shipping Method?
Customized items are negotiable. 1-3working day after payment arranges the shipping. Parcels shipping by sea, by air, or by express (EMS, UPS, DHL, TNT, FEDEX etc)