China Factory Customized CAS 111-58-0 Oleoylethanolamide

Model NO.
111-58-0
Psa
49.33000
Logp
6.36
Exact Mass
325.298065
Index of Refraction
1.474
Storage Condition
−20°c
Vapour Pressure
0.0±2.9 Mmhg at 25°c
Molecular Formula
C20h39no2
Flash Point
254.0±26.8 °c
Molecular Weight
325.529
Boiling Point
496.4±38.0 °c at 760 Mmhg
Melting Point
50-60ºC
Density
0.9±0.1 g/cm3
Transport Package
Bags
Specification
10*10*10
Trademark
Bester
Origin
China
Production Capacity
1000/Metric Ton/Months
Reference Price
$ 9.00 - 45.00

Product Description

China Factory Customized CAS 111-58-0 Oleoylethanolamide
♦1. The product quality has passed the professional production process and quality inspection, and the purity is more than 99%;
♦ 2. The products shall be packed in special standard barrels or according to the requirements of customers. All packages should be carefully transported and protected according to customer requirements;
♦3. The product from the raw material procurement, production planning, feeding capacity, production process, FG testing, warehousing inspection and other aspects of the whole process of quality control, strict supervision, through the authenticity, accuracy, timeliness and integrity of data records, to ensure the continuous improvement of product quality, and to put an end to all non-standard phenomen;
♦4. Our products are of high quality and low price, and we have sufficient stock. We will send COA and product related information to you as soon as we receive your email

China Factory Customized CAS 111-58-0 Oleoylethanolamide

Product Description

Oleoylethanolamide Biological Activity

Description Oleoylethanolamide is a high affinity endogenous PPAR-α agonist, which plays an important role in the treatment of obesity and arteriosclerosis.
Related Catalog
Natural Products   >>   Others
Research Areas   >>   Cardiovascular Disease
Research Areas   >>   Metabolic Disease
Target

Human Endogenous Metabolite

PPAR-α

In Vitro
In Vivo Oleoylethanolamide (OEA) can significantly suppress the pro-fibrotic cytokine TGF-β1 negatively regulate genes in the TGF-β1 signaling pathway (α-SMA, collagen 1a, and collagen 3a) in mice models of hepatic fibrosis. Treatment with Oleoylethanolamide (5 mg/kg/day, intraperitoneal injection, i.p.) significantly attenuates the progress of liver fibrosis in both two experimental animal models by blocking the activation of hepatic stellate cells (HSCs)[1].
Cell Assay CFSC, HSC cell lines are first obtained from cirrhotic rat liver, and have a similar phenotype to that of early passage primary HSCs. CFSC cells are cultured in Dulbecco's modified Eagle's medium (DMEM) supplemented with 10% fetal bovine serum (FBS) and 1% penicillin/streptomycin. All cells are cultured in 6-well culture plates under 37°C and 5% CO2 in an incubator. The medium is replaced every two days, and the cells are harvested and diluted at a ratio of 1:3 twice a week. In experiments, HSCs are pretreated with the experimental concentration of Oleoylethanolamide (30 μM, 10 μM, 3 μM) before stimulation with 5 ng/mL TGF-β1. mRNA expression levels of α-SMA (A) and Col1a (B) are analyzed by real-time PCR[1].
Animal Admin Mice[1] The Sv/129 mice and PPAR-α knockout mice are maintained in a room with controlled temperature (21-23°C), humidity (55-60%) and lighting (12 h light/dark cycles) and given water ad libitum. Mice are randomly divided for methionine choline-deficient (MCD) and thioacetamide (TAA) experiments. In the MCD-diet feeding experiment, wild-type Sv/129 mice and PPAR-α knockout mice are each divided into three groups (n=8 /group): (i) control group receive normal diet; (ii) fed with MCD diet and injected with the vehicle (5% Tween-80+5% PEG400+90% saline, 5 mL/kg/day, 8 weeks, intraperitoneal injection, i.p.); (iii) fed with MCD diet along with Oleoylethanolamide administration (5 mg/kg/day; 8 weeks, i.p.). In another set of experiment, all the wild-type mice and PPAR-α knockout mice are given standard chow diet, and are randomly separated into three groups: the control group is not administrated TAA or Oleoylethanolamide but is injected with the saline; the TAA group is injected with TAA (160 mg/kg, three times per week, 6 weeks, dissolved in saline, i.p.) plus the corresponding vehicle; the Oleoylethanolamide group is both injected with TAA and Oleoylethanolamide (5 mg/kg/day; 6 weeks, i.p.)[1].
 
Density 0.9±0.1 g/cm3
Boiling Point 496.4±38.0 °C at 760 mmHg
Melting Point 50-60ºC
Molecular Formula C 20 H 39 NO 2
Molecular Weight 325.529
Flash Point 254.0±26.8 °C
Exact Mass 325.298065
PSA 49.33000
LogP 6.36
Vapour Pressure 0.0±2.9 mmHg at 25°C
Index of Refraction 1.474
Storage condition −20°C
China Factory Customized CAS 111-58-0 Oleoylethanolamide
Certifications

China Factory Customized CAS 111-58-0 Oleoylethanolamide

Packaging & Shipping
  By Courier By Air By Sea  
  ≤50kg            50kg-500kg       ≥500kgs                       
  3-7 Days 5-7 Days 15-40 Days  
   Door to Door Airport to Airport Seaport to Seaport  
   Easy to get products Need do custom clearance Need do custom clearance  
Payment Terms: Western Union, MoneyGram, T/T, Bank Transfer; Bitcoin
Delivery time: 1-3 working days after confirming the payment
Delivery:  Door to Door,safety gurantee
4 big express: DHL, TNT, FedEx, UPS
Post: HKEMS, etc.
Bulk quantity for special line, guarantee safety
Packaging Details: If customer no special request, normally and safe pack.
Plastic bag & kraft paper bag & fiber drum  
1kg per bag/drum; 25kg per bag/drum
Supply Ability: Bulk quantity in stock
♦1,EMS, DHL, UPS or Fedex are used to order products. We will choose the best transportation mode according to the actual situation of customers to ensure the fastest delivery of goods;
♦2,If the mail fails or the product quality fails to meet the target requirements, we will promise to refund according to the contract;
♦3,We will deliver the goods within 7 days after receiving your payment. If you need to cancel or change the order, please let us know within 24 hours after payment;
♦4,If there are problems in the use of the product, please contact us in time, we will provide corresponding technical guidance and efficient and high-quality service;
Our service tenet is: Service is the foundation, quality is the survival and science and technology is the development.

China Factory Customized CAS 111-58-0 Oleoylethanolamide China Factory Customized CAS 111-58-0 Oleoylethanolamide

Company Profile


Hebei Best Biotechnology Co., Ltd. is a modern advanced enterprise specializing in production and exportation of APIs, Pharmaceutical intermediates, peptides, plant extracts etc. Our products are widely used in medicine, health care products, cosmetics, nutritional supplements and food additives areas. Our factory covers an area of 95 acres, the proposed construction of the plant will be GMP standards, the factory environment clean and tidy, rational layout, with large and medium-sized production workshop and repocessed shop. It is equipped with advanced equipment quality inspection and research center. Those products of both quality and technical content have reached the domestic advanced level. Since its establishment, the company has attached great importance to the team training and technical reform. Our modern production equipment guarantees for a fast and effective production with a superior degree of accuracy throughout the whole production line, everything is done in-house, processing, extraction, packaging and transportation of all links, ensuring maximum quality and efficiency. We are constantly research and development new ingredients and innovative new products, have earned the respect & Admiration from the worldwide customers. After years of continuous development, company has been accumulated rich experience in international trade and customer resources, established a stable customer base and perfect marketing service network. In addition, the company has established long-term technical cooperation with experts and professors from many universities and research institutes in the province. Excellent quality, reasonable price, rapid delivery and good service ensure us to satisfy all kinds of your demands. As a way to use the resource on the expanding info in international trade, we welcome prospects from everywhere on the web and offline. In spite on the high quality items we offer, effective and satisfying consultation service is supplied by our qualified after-sale service group. Item lists and detailed parameters and any other info weil be sent to you timely for the inquiries. So please make contact with us by sending us emails or call us when you′ve got any questions about our organization.
China Factory Customized CAS 111-58-0 Oleoylethanolamide

 

Our Advantages

1. Rich experience
We specialize in this filed for many years,our steriods and hormones exported to all over the world and established long friendly relations of cooperation with them.
2. Great quality,purity and favorable
Good quality is one of our biggest secret to success;u can get the best quality and service from us.
3. Safest and fastest delivery
We have adequate stock so that we can deliver the products with 24 hours as soon as receiving the payment.Fast and discreet shipment will be arranged to pass customs.
4. Good package
Unique ways to ship 10g to 100kg powders to your destination.We offer melting powder into liquid service and ship the liquid in special bottles.
5. Great after-sales service
Any needs or questions contact me freely.

FAQ

Q1: What is your MOQ
A:Our MOQ is 10g, 100g and 1kg for your evaluation quality of our goods on the condition that sample charge is 100% paid.
Q2: Is there any discount
A:Yes, for larger quantity, we always support with better price.
Q3: What payment terms do you accept
A:We'd like to accept T/T, L/C, Paypal, or Western Union.
Q4: How long will it take to get the goods
A:Depending on your location, For small order, please expect 5-7 days by DHL, UPS, TNT, FEDEX, EMS. For mass order, please allow 5-8 days by Air, 20-35 days by Sea.
Q5: How do you treat quality complaint
A: First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.
Q6: How can we trust you
A: You are always warmly welcomed to visit us at any time. Before we start B2B, MIC has audited our company on-spot and approved our credit.
Q7: Do you test all your goods before delivery
A: Yes, we have 100% test before delivery,International Authorized Third-Party Test for the products if you need are highly welcomed.

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