2-MERCAPTO-5-METHOXYBENZIMIDAZOLE Chemical Properties |
Melting point | 261-263 °C(lit.) |
Boiling point | 309.4±44.0 °C(Predicted) |
density | 1.2425 (rough estimate) |
refractive index | 1.5690 (estimate) |
storage temp. | 2-8°C |
pka | 10.13±0.30(Predicted) |
form | Powder |
color | Off-white to light yellow-brown |
Water Solubility | insoluble |
Sensitive | Air Sensitive |
BRN | 3605123 |
CAS DataBase Reference | 37052-78-1(CAS DataBase Reference) |
Safety Information |
Hazard Codes | Xi,Xn |
Risk Statements | 36/37/38-37-22 |
Safety Statements | 26-36 |
WGK Germany | 3 |
Hazard Note | Irritant |
HazardClass | IRRITANT |
HS Code | 29332900 |
2-MERCAPTO-5-METHOXYBENZIMIDAZOLE Usage And Synthesis |
Description | 2-Mercapto-5-methoxybenzimidazole is used in the preparation of COX-2 inhibitors. It is also employed in the preparation of compounds such as 5-methoxy-2[[(4-methoxy-3, 5-dimethyl-2-pyridinyl) methyl] sulfonyl]-1H-benzimidazole, 5-methoxy-2[[(4-methoxy-3, 5-dimethylpyridin-2-yl-1-oxide) methyl] sulfonyl]-1H-benzimidazole as well as tris[μ-1,2-bis(diphenylphosphino)et hane]-1:2κ2P:P′;1:3κ2P:P′;2:3κ2P:P′-di-μ-bromido-1:2κ4Br:Br-bromido-3κBr-tricopper(I) ace tone hemisolvate. Furthermore, it acts as a hetercocyclic building block and serves as an intermediate of drug omeprazole1. Finally, it acts as an intermediate for manufacture of the anti-ulcer drug Omeprazole. |
Chemical Properties | off-white to light yellowish-brown powder |
Uses | Reagent used in the synthesis of COX-2 inhibitors |