N-acetyl Neuraminic acid is the most widely distributed Sialic acid (N-acyl Neuraminic acid) in nature, which is mainly composed of glycoprotein, glycolipid or bacterial capsule substances in animal cell membrane or secretion. In glycoproteins or glycolipids, because the 2-position ketone group forms a Glycosidic bond, it is located at the non reducing end of the sugar side chain. Its negative charge or unique chemical structure makes it have various physiological specificity. The enzyme that hydrolyzes and removes terminal N-acetyl Neuraminic acid (Neuraminic acid glycosidase) is widely distributed in nature, from viruses to animals. The physiological activity changes of the enzyme Chemicalbook by processing the enzyme have clarified the role of this terminal acid sugar residue. For example, this sugar residue forms the binding site of influenza virus on the Red blood cell membrane and plays a major role in the mutual recognition of plasma glycoprotein and liver cells or the recognition mechanism of lymphocytes on the circulatory pathway. Although the biosynthetic pathway is somewhat different in animals and bacteria, it passes through N-acetyl Mannosamine or its 6-phosphate, which is catalyzed by specific Pyrophosphatase and reacts with CTP to produce CMP N-acetyl Neuraminic acid, which is then incorporated into the sugar chain by glycosyl transfer reaction. | ||
ph value: | 2.41±0.54(Predicted) | |
SOLUBLE: | 50 g/L (20 ºC) | |
density : | 1.3580 (rough estimate) |