Puya Supply Axitinib CAS 319460-85-0 For Anti Tumour

Product Name:    Axitinib
Synonyms:    N-METHYL-2-{[3-((E)-2-PYRIDIN-2-YLVINYL)-1H-INDAZOL-6-YL]SULFANYL}BENZAMIDE;N-Methyl-2-((3-((1E)-2-(pyridin-2-yl)ethenyl)-1H-indazol-6-yl)sulfanyl)benzamide;AVERMECTINB;Axitinib for research;AG 013736;N-Methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]benzamide;Benzamide, N-methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]-;AG013736; AG 013736; AG-013736; AXITINIB; BRAND NAME: INLYTA.
CAS:    319460-85-0
MF:    C22H18N4OS
MW:    386.47
EINECS:    638-771-6
Product Categories:    Pfizer compounds;API;All Inhibitors;Inhibitors;AG 013736;chemical;Intermediates & Fine Chemicals;Pharmaceuticals;Protein Kinase Inhibitors and Activators
Mol File:    319460-85-0.mol



Axitinib is a VEGFR inhibitor (IC50s = 1.2, 0.25, and 0.29 nM for VEGFR1, -2, and -3, respectively). It also inhibits c-Kit and PDGFRβ (IC50s = 1.7 and 1.6 nM, respectively). It inhibits VEGF-induced migration of and tube formation by human umbilical vein endothelial cells (HUVECs). Axitinib (1-100 mg/kg) reduces microvessel density, a marker of angiogenesis, and tumor growth in MV522 colon carcinoma, A375 melanoma, SN12C-GFP renal carcinoma, and U87 glioma mouse xenograft models in a dose-dependent manner. Formulations containing axitinib have been used in the treatment of renal cell carcinoma.


Axitinib CAS 319460-85-0 of Chemical Properties
Melting point     213-215°C
Boiling point     668.9±55.0 °C(Predicted)
density     1.4
storage temp.     room temp
solubility     DMSO: ≥8mg/mL
form     powder
pka    12.70±0.40(Predicted)
color     white to tan
Stability:    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKey    RITAVMQDGBJQJZ-FMIVXFBMSA-N
CAS DataBase Reference    319460-85-0(CAS DataBase Reference)



Function and Application of Axitinib CAS 319460-85-0

Axitinib (CAS 319460-85-0) is a potent and selective small molecule inhibitor of vascular endothelial growth fac tor receptors (VEGFR) 1, 2, and 3. It is an orally administered drug that is used to treat certain types of advanced kidney cancer.

Function: Axitinib functions by blocking the growth and spread of cancer cells by inhibiting the formation of new blood vessels that supply nutrients and oxygen to the tumor. By blocking VEGFR signaling, axitinib reduces the ability of the cancer cells to form new blood vessels and deprives them of the oxygen and nutrients needed for their growth and survival.

Application: Axitinib is mainly used to treat advanced renal cell carcinoma (RCC) that has not responded to other treatments. It is also sometimes used to treat other types of cancer, such as thyroid cancer. Axitinib is usually taken orally as a tablet, and its dosage and treatment duration are determined by the doctor based on the patient's condition, age, weight, and other factors.

Company Profile
Anhui puya biological technology co.,ltd was established in Hefei. Registered capital is 5 million. It is specialized in manufacture plant extract, API and chemicals raw material powder, food additives and oil. which are applied to skin care, healthcare, weight loss products, sex improvement, and pharmaceuticals. We will uphold honesty and pragmatic, innovative and enterprising service purposes, and provide a variety of quality services to our customers at abroad. It aims at supplying good product and comfort service. The strict quality control is to meet the customer's requirement, to get a highly praised and to be high quality supplier. If you have any question, or need samples, please feel free to contact us.

FAQ
Q1. What's the MOQ?
A: Usually 1 kg.  It is based on the different product. Some are 1g and some are 1 ton. Please be free to consult our salesman.
 
Q2. What's the shipping time?
A: If in stock, we will ship it out immediately.  By FedEx will be 3~5 days to you.
 
Q3. If I need less than the MOQ, is it possible?
A: Yes. Please be free to consult our salesman.
 
Q4. Can you supply the free sample?
A: Usually it is possible. but the shipping cost be paid by customers. It based on the different product. Please be free to consult our salesman.
 
Q5. How to store the product?
A: Store in cool and dry place. It must be in well closed containers. The shelf life will be 2 years.
 
Q6: What's your main payment method?
A: T/T, trade assurance, west union, money gram.
 
Q7: Do you have COA, MSDS, CO, Health certificate, form 9 or other certificate?
A: Yes, we have. pls be free to contact us to get updated one.